Anti-FEN1 Antibody

Raised in rabbit, this polyclonal primary antibody targets FEN1 (Flap Endonuclease 1), a structure-specific endonuclease essential for Okazaki fragment maturation during DNA replication and for long-patch base excision repair. The unconjugated reagent is supplied at 100 µl and is validated for Western blot (WB), immunohistochemistry (IHC), and immunofluorescence (IF) workflows, making it a flexible tool across imaging and biochemical readouts.

FEN1 removes 5' overhanging flap structures generated during lagging-strand synthesis and processes branched DNA intermediates, positioning it as a focal protein in studies of genomic stability, the DNA damage response, and cancer biology. The antibody cross-reacts with Human, Mouse, and Rat samples, supporting comparative work between patient-derived material and standard model systems such as rodent tissue.

Distributed by Antibodies.com for research use only, the reagent is compatible with common chromogenic and fluorescence-based detection chemistries, allowing straightforward integration into multi-antibody panels that interrogate components of the DNA repair machinery.