Anti-FDPS Antibody

Farnesyl diphosphate synthase (FDPS) catalyzes a branch-point step in the mevalonate pathway, condensing isopentenyl diphosphate with dimethylallyl diphosphate to yield the C15 isoprenoid precursor used in squalene, dolichol, and protein prenylation biosynthesis. This polyclonal reagent from Antibodies.com, raised in rabbit and supplied as 100 µL of unconjugated antiserum in a single vial, is validated for Western blot and immunohistochemistry workflows and reacts with human, mouse, and rat samples. Researchers studying bone-resorption biology, osteoclast differentiation, statin- and bisphosphonate-sensitive cell signaling, or tumor lipid metabolism commonly use FDPS expression as a mevalonate-pathway read-out.

Because the antibody is polyclonal, it recognizes multiple epitopes across the FDPS polypeptide, which preserves signal on full-length enzyme in tissue lysates and fixed sections where monoclonal reagents can drop binding at denatured epitopes. It pairs naturally with downstream prenylation markers such as Ras, Rho, and lamin A when dissecting pathway flux, and is frequently combined with cathepsin K and TRAP staining in osteoclast-focused histology panels. Aliquot upon first thaw to limit freeze-thaw cycles; store short term at 4 °C, and for longer keeping snap-freeze working aliquots and hold at -20 °C or below, protected from light.