Anti-FCGR3A Antibody

FCGR3A, also known as CD16a, is the high-affinity Fc gamma receptor that drives antibody-dependent cellular cytotoxicity on natural killer cells and macrophages. The Rabbit polyclonal primary antibody from Antibodies.com is raised against human FCGR3A and validated for Western blot and immunohistochemistry workflows.

Supplied unconjugated at 1 mg/ml in PBS with 0.1% Sodium Azide and 50% glycerol as cryoprotectant, each 100 µl vial offers flexible pairing with HRP, biotin, or alkaline phosphatase secondaries chosen by the laboratory. Polyclonal reactivity yields broader epitope coverage, useful for probing across the well-characterised FCGR3A polymorphic variants V158 and F158 that differ in IgG binding affinity and modulate ADCC strength during therapeutic antibody responses.

Applications include research into NK cell effector function, Fc gamma receptor signalling, and immunotherapy response biomarkers. Store at -20°C; aliquot upon receipt to limit freeze-thaw cycles and preserve reagent performance across extended studies.