Anti-FCGR2A Antibody

FCGR2A, the low-affinity IgG Fc receptor expressed on macrophages, neutrophils, and other myeloid lineage cells, can be detected using this unconjugated rabbit polyclonal antibody from Antibodies.com. Validated for western blot, immunohistochemistry, and immunofluorescence on human samples, the reagent supports studies of receptor distribution, ITAM-mediated signaling, and downstream effector functions such as phagocytosis and antibody-dependent cellular cytotoxicity.

The polyclonal format enables recognition of multiple epitopes across the FCGR2A extracellular domain, an advantage when probing primary tissues or heterogeneous cell populations where receptor expression may differ between cell types and activation states. The unconjugated presentation allows researchers to select fluorophore conjugates, enzyme labels, or biotin-based detection chemistries according to the specific demands of their experimental setup.

FCGR2A biology has particular relevance to autoimmune and inflammatory disease research because the receptor couples IgG-containing immune complexes to innate effector responses. The well-characterized histidine/arginine polymorphism at position 131 modulates IgG subclass binding affinity and has been examined in contexts including susceptibility and clinical course in systemic lupus erythematosus and rheumatoid arthritis, as well as responses to bacterial pathogens. The antibody is supplied as a 100 µl liquid volume, ready to use in standard immunolabelling workflows.