Anti-FBXW7 Antibody

A rabbit polyclonal primary reagent from Antibodies.com provides an unconjugated IgG option for detecting FBXW7 in human, mouse, and rat samples. The supplied 50 µl vial supports western blot, immunohistochemistry, and immunofluorescence workflows—for example, examining protein abundance in lysates, staining patterns in tissue sections, or subcellular distribution in cultured cells.

FBXW7 is the substrate-recognition component of the SCF E3 ubiquitin ligase complex and promotes the ubiquitination and proteasomal degradation of oncoproteins including cyclin E, c-Myc, Notch, and c-Jun. This makes the antibody useful for cancer biology studies, including comparisons of FBXW7 status in colorectal, gastric, and endometrial tumor materials and experiments investigating cell-cycle control and oncoprotein turnover.

Because the antibody is unconjugated, labeling and detection chemistry can be selected according to the experimental system. For continuous use, store at -20°C and avoid repeated freeze-thaw cycles. Dilution, fixation or permeabilization conditions, and appropriate experimental controls should be optimized for each application and sample type.