Anti-FBXW7 Antibody

Used to detect F-box and WD repeat domain-containing 7 (FBXW7) by Western blot, this rabbit polyclonal IgG reagent from Antibodies.com is supplied as an unconjugated 200 µL liquid aliquot.

FBXW7 acts as the substrate-recognition component of the SCF E3 ubiquitin ligase complex, directing ubiquitination and proteasomal turnover of several oncoprotein substrates including cyclin E, c-Myc, c-Jun, and Notch, which is why the protein is a focus of cell-cycle, differentiation, and tumor suppressor research.

The antibody cross-reacts with human and mouse samples, supporting comparative work between cell-line and tissue-derived lysates, and is commonly applied to whole-cell extracts to assess steady-state FBXW7 levels alongside pathway readouts such as cyclin E accumulation or Notch cleavage.