Anti-FBXW7 Antibody

This rabbit polyclonal IgG antibody specifically recognizes FBXW7, an F-box and WD repeat domain-containing protein that functions as a substrate adaptor within the SCF (Skp1-Cul1-F-box) E3 ubiquitin ligase complex. FBXW7 directs key oncoproteins, including c-Myc, cyclin E, Notch, and c-Jun, toward proteasomal degradation, making it a critical controller of cell cycle progression, proliferation, and differentiation in both normal and malignant tissues.

Provided as 100 µl of unconjugated antibody, the reagent is validated for western blot applications and shows reactivity with human and mouse samples. Researchers use it to investigate tumor suppressor signaling, the ubiquitin-proteasome pathway, and the consequences of FBXW7 loss-of-function mutations that are frequently observed in colorectal, gastric, and other cancers.

As a primary antibody from Antibodies.com, it enables studies of how FBXW7 substrate turnover shapes cellular outcomes and supports oncology research into related therapeutic strategies.