Anti-FBXO11 Antibody

Produced in rabbit and supplied as 100 µl of unconjugated polyclonal serum from Antibodies.com, this reagent targets FBXO11, the substrate-recognition subunit of an SCF (Skp1–Cullin1–F-box) E3 ubiquitin ligase that marks client proteins for proteasomal turnover. Endogenous reactivity is confirmed on human, mouse, and rat samples, with validated use in Western blot and immunofluorescence workflows. FBXO11 is the F-box protein most closely tied to ubiquitin-dependent control of BCL6 in germinal-centre B cells, and somatic loss-of-function alterations are recurrent in diffuse large B-cell lymphoma, while the same ligase activity contributes to p53 stability and TGF-β-driven transcription. Investigators deploy the antibody to track endogenous FBXO11 in lymphoma cell lines, cortical neurons, and engineered knockout or knockdown systems, and the unconjugated format permits pairing with HRP- or fluorophore-labelled secondary reagents. Aliquot on receipt and store refrigerated to limit repeated freeze-thaw cycles of the polyclonal antibodies.