Anti-FBXO11 Antibody

This rabbit polyclonal primary antibody from Antibodies.com is raised against FBXO11, an F-box substrate adaptor that recruits proteins such as BCL6 into the SCF E3 ubiquitin ligase complex for ubiquitin-dependent proteasomal turnover. Provided as an unconjugated IgG at a 50 µl pack size, the reagent is validated for Western blot and immunofluorescence detection of endogenous FBXO11 in human and mouse samples.

The unconjugated format supports flexible pairing with HRP-, fluorophore-, or biotin-conjugated secondary antibodies, enabling cell lysate analysis by Western blot and visualization of FBXO11 distribution in fixed tissue sections or cultured cells by immunofluorescence. FBXO11 biology intersects with oncology research through BCL6 regulation, with neurodevelopmental studies where loss-of-function mutations have been linked to intellectual disability, and with ubiquitin–proteasome pathway investigations including DNA damage response signaling.

Storage at -20 °C preserves antibody activity across long-term use, with aliquoting recommended to limit repeated freeze-thaw cycles. Each vial is affinity purified and supplied in an unconjugated format that allows researchers to attach the label of their choice.