Anti-FBXO11 Antibody

FBXO11 (F-box only protein 11, also called VIT-1/PRMT9) acts as the substrate-recognition subunit of the SCF (Skp1-Cullin1-F-box) E3 ubiquitin-protein ligase complex, recruiting proteins such as BCL6, DTL/CDT2, PRDM1/BLIMP1, and neddylated p53/TP53 for ubiquitin-mediated proteasomal degradation. The unconjugated affinity-purified rabbit polyclonal IgG reagent from Antibodies.com is raised against recombinant human FBXO11 and supplied as a 200 µl aliquot in a PBS-based buffer containing glycerol and sodium azide. It detects endogenous total FBXO11 in human and mouse samples by Western blot and immunofluorescence, supporting research on germinal center B-cell terminal differentiation toward memory B-cells and plasma cells, diffuse large B-cell lymphoma biology, the TGF-β signaling cascade, vitiligo-associated pigmentation mechanisms, and the broader ubiquitin-proteasome system in which FBXO11 is studied as a tumor suppressor and regulator of oncogenic transcription factors.

For best results, aliquot the stock upon arrival and store at -20°C in working volumes to limit freeze-thaw cycles; avoid repeated freeze-thaw of the original vial. Brief centrifugation before opening helps recover full volume. This reagent is intended for research use only and is not approved for diagnostic or therapeutic applications.