Anti-FBXL3 Antibody

Raised in rabbit against the FBXL3 F-box protein, this unconjugated polyclonal antibody enables detection of the substrate-recognition subunit of an SCF E3 ubiquitin ligase complex in human samples. FBXL3 directs the ubiquitin-dependent turnover of cryptochrome proteins CRY1 and CRY2, placing it at the center of circadian rhythm regulation and period-length control, with documented phenotypes linked to the after-hours and overtime gain-of-function alleles. The reagent is provided as 100 µl of unconjugated rabbit polyclonal Ig fraction and supports both Western blot and immunofluorescence workflows on human cells and tissue. Researchers studying clock gene regulation, F-box protein biology, SCF complex assembly, or proteasomal substrate turnover can apply it to characterize FBXL3 expression levels, subcellular localization across the day-night cycle, and changes following proteasome or cryptochrome perturbation. Routine refrigerated storage with aliquoting to limit freeze-thaw exposure preserves performance across extended Western blot and imaging campaigns. Sourced and quality-controlled by Antibodies.com as a Primary Antibodies reagent for research use only.