Anti-FBL Antibody

Recognizes Fibrillarin (FBL), a conserved ~34 kDa nucleolar methyltransferase that catalyzes 2'-O-methylation of ribosomal RNAs and supports ribosome biogenesis in eukaryotic cells. The reagent is a Rabbit polyclonal antibody supplied as 100 µl of unconjugated antiserum, validated for western blot, immunohistochemistry, and immunofluorescence in Human, Mouse, and Rat samples.

Fibrillarin concentrates in the dense fibrillar component of the nucleolus, and this antibody is frequently adopted as a nucleolar marker to study nucleolar architecture, Cajal body dynamics, and rRNA maturation. Researchers also apply it to track nucleolar stress responses in cancer models, characterize ribosomopathies, and probe altered rRNA processing in neurodegeneration and aging research.

Polyclonal Antibodies.com reagents offer epitope diversity, which helps preserve signal when working with limited material from primary cells or laser-microdissected tissue. For best results, store refrigerated and aliquot upon arrival to limit freeze-thaw cycles and preserve antibody titer across long-term studies.