Anti-FBL Antibody

A conserved ~34 kDa nucleolar protein, fibrillarin (FBL) catalyzes 2'-O-methylation of ribosomal RNA and serves as a defining marker of the dense fibrillar component of the nucleolus and Cajal bodies. This polyclonal rabbit reagent from Antibodies.com, supplied as a 50 µl aliquot at 1 mg/ml in PBS with 0.1% sodium azide and 50% glycerol, recognizes the FBL target and is unconjugated for flexible pairing with rabbit-compatible secondary antibodies. Validated applications include western blot, immunohistochemistry, immunofluorescence, immunoprecipitation, and RNA immunoprecipitation, with reactivity confirmed on human, mouse, and rat samples. Researchers commonly deploy the antibody in nucleolar marker co-localization assays, rRNA biogenesis studies, and stress-response investigations where nucleolar morphology shifts. Store frozen at -20 °C in the supplied glycerol buffer, limit freeze-thaw cycles, and protect from light to preserve activity across long-term use.