Anti-FAS Antibody

Raised in rabbit, this unconjugated polyclonal reagent from Antibodies.com is supplied as 100 µl of antiserum validated for Western blot and immunohistochemistry on human samples.

FAS, also known as CD95 or TNFRSF6, is a member of the tumor necrosis factor receptor superfamily that triggers the extrinsic apoptosis pathway upon binding by FAS ligand. The antibody is widely used to study programmed cell death in lymphoid and non-lymphoid tissues, with applications including autoimmune lymphoproliferative syndrome research, lymphoma and melanoma biology, T-cell activation models, and characterization of death-inducing signaling complex assembly.

Researchers apply anti-FAS antibodies to monitor receptor expression in cell culture, track clustering at the plasma membrane, and correlate protein levels with susceptibility to ligand-induced apoptosis in tissue sections. The polyclonal format provides multiple epitope recognition, supporting consistent detection across denaturing and fixed sample preparations.