Anti-FARSB Antibody

This Rabbit polyclonal primary antibody from Antibodies.com targets FARSB (Phenylalanyl-tRNA Synthetase Subunit Beta), a mitochondrial aminoacyl-tRNA synthetase that catalyzes the charging of tRNA with phenylalanine during protein biosynthesis. Raised in rabbit and supplied in a 100 µL vial of unconjugated antiserum, the reagent is validated for Western blot and immunohistochemistry on human samples. FARSB localizes to the mitochondrial matrix, where it functions as the beta subunit of the heterotetrameric phenylalanyl-tRNA synthetase complex, working alongside the alpha subunit (FARSA) to ensure accurate translation of mitochondrial-encoded transcripts.

Research interest in FARSB extends well beyond its canonical role in mitochondrial translation: biallelic loss-of-function variants in the gene have been linked to Rajab interstitial lung disease with brain abnormalities, and altered expression has been investigated in the context of certain cancers and neurodegenerative conditions. This makes the antibody a useful reagent for investigators studying mitochondrial translation, rare genetic disease mechanisms, or tissue-level expression patterns of aminoacyl-tRNA synthetases. The polyclonal format provides recognition of multiple epitopes on the FARSB target, which can support more robust detection in tissues where antigen abundance varies, and the unconjugated formulation allows researchers to pair the antibody with their preferred secondary detection reagents and labels.