Anti-FANCC Antibody

This polyclonal antibody from Antibodies.com targets FANCC (Fanconi Anemia Complementation Group C), a 558-amino-acid component of the FA core complex that orchestrates monoubiquitination of the FANCD2/FANCI heterodimer during the cellular response to DNA interstrand crosslinks. Raised in rabbit and supplied as an unconjugated, affinity-purified IgG preparation in 100 µl, the reagent is validated for western blot, immunohistochemistry, and immunofluorescence on human samples, supporting studies in DNA damage repair, bone marrow failure, and tumor suppressor biology.

FANCC resides in both the cytoplasm and nucleus, where it participates in cytokine-mediated signaling, apoptosis regulation, and S-phase checkpoint control, making the antigen relevant to leukemia research, chemoresistance investigations, and Fanconi anemia complementation group C studies. Researchers commonly detect the endogenous protein in HeLa, HEK293, and lymphoblastoid cell lines, with bands near 50-60 kDa depending on isoform and post-translational modification. Store the vial at -20 °C in working aliquots to limit freeze-thaw cycles, and protect from light; the conjugate-free format allows pairing with HRP, fluorophore, or biotin secondary reagents of the user's choice. Intended for research use only.