Anti-Factor B Antibody (HRP) [KT24] - Identical to Abcam (ab106687)

The KT24 clone is one of the most widely cited monoclonal reagents targeting human Factor B, a 90 kDa single-chain glycoprotein that circulates at roughly 200 µg/mL in normal serum and provides the catalytic subunit of the alternative-pathway C3 convertase. Factor B is cleaved by Factor D into the Ba fragment and the Bb serine-protease fragment, and Bb then assembles with C3b to form the C3bBb convertase that drives amplification of complement activation.

Antibodies.com supplies this reagent as an HRP-conjugated detection antibody, formatted as 100 µg of liquid in a single vial and intended for matched-pair immunoassays quantifying Factor B in research samples. The mouse IgG1 background matches the published reference clone, and the liquid formulation allows direct dilution into assay buffer without further conjugation steps. Specificity is directed at the human protein, with no significant cross-reactivity reported for mouse or rat Factor B, supporting routine use in human complement biology, immunology, vaccine research, and clinical biomarker studies of alternative-pathway activation.

Store refrigerated at 4 °C for short-term use, or aliquot and freeze at -20 °C or lower for long-term storage; protect the vial from light to preserve HRP enzymatic activity and minimize freeze-thaw cycles. The conjugate pairs cleanly with appropriate anti-Factor B capture antibodies in matched-pair immunoassays measuring complement activation in clinical research samples.