Anti-EZH2 Antibody

This unconjugated polyclonal reagent from Antibodies.com selectively recognizes EZH2 (Enhancer of Zeste Homolog 2), the catalytic methyltransferase subunit of Polycomb Repressive Complex 2 responsible for depositing repressive H3K27me3 marks across chromatin. Raised in rabbit, the antibody is supplied in a vial containing 100 µl and has been validated for western blot, immunohistochemistry, and immunofluorescence applications on human, mouse, and rat samples. EZH2 sits at the crossroads of development and disease: it is essential for X-chromosome inactivation, embryonic stem cell self-renewal, and lineage commitment, while gain-of-function mutations and overexpression are recurrent drivers in diffuse large B-cell lymphoma, follicular lymphoma, and a range of solid tumours, making the protein a focal target for epigenetic drug discovery. Researchers use this reagent to profile PRC2 activity in tumour biopsies, characterise differentiation programs in stem cell models, and benchmark the on-target effects of small-molecule EZH2 inhibitors. For long-term integrity the preparation should be stored frozen in single-use aliquots and protected from repeated freeze-thaw cycles.