Anti-EZH2 Antibody

Targeting EZH2 (Enhancer of Zeste Homolog 2), the catalytic subunit of Polycomb Repressive Complex 2, this rabbit polyclonal IgG antibody from Antibodies.com supports chromatin and epigenetics research workflows. The unconjugated reagent is supplied as 200 µl of polyclonal IgG and is validated for Western blot, immunohistochemistry, immunofluorescence, and flow cytometry on human and mouse samples.

EZH2 catalyzes trimethylation of histone H3 at lysine 27 (H3K27me3), a repressive chromatin mark implicated in X-inactivation, stem cell maintenance, and silencing of tumor suppressor genes. Researchers working with prostate, breast, and lymphoma models — where EZH2 is frequently overexpressed or carrying activating mutations — use this reagent to track PRC2 activity, monitor differentiation states, and probe cellular responses to small-molecule EZH2 inhibitors. The polyclonal host format provides broader epitope coverage than a monoclonal clone, which is helpful when surveying both wild-type and variant EZH2 proteins across multiple sample types.