Anti-Exostosin-like 3 Antibody

The Antibodies.com primary antibody reagent targets Exostosin-like 3 (EXTL3), a Golgi-resident glycosyltransferase that initiates heparan sulfate chain elongation on proteoglycan core proteins. Raised in rabbit, this polyclonal reagent is supplied as an unconjugated 100 µg vial for Western blot and immunohistochemistry workflows on human samples.

EXTL3 has emerged as a regulator of multiple signaling pathways: it functions as a receptor for reggie/flotillin proteins and modulates Wnt/β-catenin and PI3K/AKT activity, while its catalytic activity contributes to the synthesis of heparan sulfate disaccharides. Researchers in stem cell biology, developmental biology, and glycosaminoglycan biochemistry have used EXTL3-targeted antibodies to probe its expression in epithelial and neural tissues, and to examine how altered EXT-family glycosylation reshapes growth factor gradients within tumor microenvironments.

The unconjugated format supports flexible pairing with custom reporter-conjugated secondary antibodies, accommodating chromogenic, fluorescence, or chemiluminescent read-outs depending on the experimental design. Storage at -20 °C in single-use aliquots helps preserve reactivity across repeated freeze-thaw cycles.