Anti-EXO1 Antibody

Exonuclease 1 (EXO1) is a 5′–3′ exonuclease that drives mismatch repair, homologous recombination, and replication-fork restart, and this rabbit polyclonal IgG reagent from Antibodies.com was raised against the human protein for direct detection by Western blot and immunofluorescence. Supplied as a 100 µl unconjugated aliquot, the antibody recognizes human EXO1 in cell lysates, tissue sections, and fixed-cell preparations without requiring a species-specific secondary beyond standard anti-rabbit reagents.

The polyclonal format offers broad epitope coverage along the EXO1 polypeptide, useful when distinguishing full-length protein from truncated splice variants or proteolytic fragments generated during DNA-damage signaling. Researchers in genome-stability, cancer biology, and DNA-repair fields apply it to monitor resection intermediates at double-strand breaks, study microsatellite-instability models, and probe chromatin-bound EXO1 pools after genotoxic stress.

For routine use, store the vial refrigerated at 4 °C; for longer projects, aliquot and freeze to limit freeze-thaw cycles and preserve activity. Each lot is quality-controlled by Antibodies.com on whole-cell lysates and fixed-cell immunofluorescence preparations to confirm specificity and batch-to-batch consistency.