Anti-EWSR1 Antibody

The EWSR1 protein (Ewing sarcoma breakpoint region 1) is a multifunctional RNA-binding factor encoded on chromosome 22q12. It is central to the study of RNA processing, transcription regulation, and the chromosomal translocations that define Ewing sarcoma and related small round cell sarcomas, where fusion oncoproteins such as EWS-FLI1 drive oncogenesis.

This unconjugated rabbit polyclonal reagent from Antibodies.com is raised against EWSR1 and validated for Western blot and immunofluorescence workflows across human, mouse, and rat sample types. The polyclonal format gives broader coverage of fusion variants than most monoclonal alternatives, supporting applications such as confirming translocation breakpoints, mapping nuclear localization patterns, and probing the protein's role in transcription-coupled RNA splicing.

Each vial is supplied at 100 µl and should be stored at -20 °C in working aliquots to limit freeze-thaw cycles, with the IgG fraction preserved for use in chromatin immunoprecipitation and immunoprecipitation protocols where EWSR1's RNA partners are pulled down together with the protein.