Anti-ETHE1 Antibody

Raised in rabbit against the mitochondrial sulfur dioxygenase ETHE1, this polyclonal antibody from Antibodies.com supports detection of the persulfide dioxygenase implicated in ethylmalonic encephalopathy, a childhood-onset metabolic disorder characterized by elevated ethylmalonic acid, lactic acidosis, and progressive neurological decline. Validated for Western blot and immunohistochemistry workflows, the unconjugated reagent permits flexible assay design with user-selected secondary reporters and chromogens, and the 100 µl vial size is suited to pilot studies, multiple-membrane probing, and limited sample cohorts.

Cross-reactivity is confirmed for human and mouse ETHE1, enabling translational research into tissue-specific expression patterns, mitochondrial dysfunction, and hydrogen sulfide detoxification pathways. Storage recommendations call for aliquoting and freezing at -20°C to preserve polyclonal reactivity across multiple freeze-thaw cycles, with working dilutions adjusted empirically for each application.

Researchers investigating sulfide metabolism, oxidative stress responses, and the molecular pathology of ETHE1 deficiency benefit from this reagent's specificity, while laboratories comparing patient-derived samples with knockout or knockdown models can integrate the antibody into multi-panel studies. Each lot is quality controlled to support reproducible band patterns in Western blot and clean signal localization in IHC preparations on formalin-fixed and frozen tissue sections.