Anti-ESR2 Antibody

Estrogen Receptor Beta (ESR2) is a ligand-activated nuclear transcription factor that mediates estrogen signaling across reproductive, neurological, cardiovascular, and immune tissues, frequently acting with distinct or opposing functions to the related ERα isoform. Researchers studying hormone-responsive cancers, neuroendocrine pathways, bone metabolism, and reproductive biology rely on ESR2 antibodies to map tissue-specific expression patterns and monitor protein-level responses to estrogenic compounds and selective modulators.

This unconjugated rabbit polyclonal reagent from Antibodies.com is supplied at 100 µl per vial and is validated for Western blot and immunohistochemistry workflows. With confirmed reactivity against human and mouse ESR2, it supports cross-species comparative studies and is suited to projects that need to localize receptor expression in fixed tissue sections or quantify receptor abundance in lysates from cultured cells and primary tissue.

Because ESR2 expression is frequently altered in breast, prostate, ovarian, colorectal, and bladder tumors, immunohistochemistry-based detection with this reagent is commonly paired with downstream transcript analyses such as qPCR or RNA-seq to correlate protein and mRNA data. In Western blot workflows, the polyclonal format offers broader epitope coverage, which helps when detecting full-length receptor, splice isoforms, or post-translationally modified species, and is useful for validating CRISPR knockouts and RNAi knockdown efficiency.