Anti-ESR1 Antibody

Rabbit polyclonal IgG from Antibodies.com raised against ESR1 is supplied as 100 µl of unconjugated affinity-purified reagent in a single-use vial, validated for Western blot (WB) and immunohistochemistry (IHC) workflows on Human, Mouse, and Rat samples. The reagent detects estrogen receptor alpha, a 66 kDa nuclear receptor that mediates ligand-activated transcription in hormone-responsive tissues including breast, uterine, and ovarian epithelium. Researchers commonly deploy this antibody to score ERα status in breast carcinoma tissue sections following ASCO-CAP guidelines, to characterize tamoxifen-resistant cell line models such as MCF-7 and T47D by Western blot, and to profile receptor expression in rodent xenograft and reproductive biology tissues. The polyclonal format supports recognition of multiple epitopes, which is useful when probing receptor isoforms or post-translational modifications relevant to endocrine resistance research. Storage is at -20°C in a formulation buffered in PBS containing 0.02% sodium azide and 50% glycerol, designed to preserve activity across routine freeze-thaw cycles. For research use only in in vitro laboratory applications.