Anti-ERp57 Antibody

A thiol-dependent oxidoreductase of the protein disulfide isomerase family, ERp57 (also known as PDIA3) resides in the endoplasmic reticulum and is captured by this rabbit polyclonal IgG from Antibodies.com. Each vial contains 100 µl of unconjugated antibody, validated for western blot and ELISA detection of the endogenous protein in human, mouse, and rat samples.

ERp57 forms a disulfide-linked heterodimer with tapasin that loads peptides onto MHC class I molecules, so the reagent supports studies of antigen presentation, ER stress and the unfolded protein response, and the calreticulin-calnexin chaperone cycle. Cancer research laboratories use it to profile ERp57 expression across breast, cervical, ovarian, and lung tumor lines, while neuroscience groups follow its redistribution under oxidative or ischemic challenge. Refrigerate the vial upon receipt and aliquot to limit freeze-thaw cycles.