Anti-ERK1 Antibody

Raised in rabbit and purified to >95% by affinity methods, this polyclonal reagent from Antibodies.com targets ERK1 (Extracellular signal-regulated kinase 1, MAPK3), a ~44 kDa serine/threonine kinase central to the MAPK/ERK signaling cascade. The antibody is supplied as 50 µl of liquid at 1 mg/ml in PBS containing 0.1% Sodium Azide and 50% glycerol, and is unconjugated, allowing direct detection with secondary reporters of the user's choice. It is validated for Western Blot (WB) and Immunohistochemistry (IHC), two of the most widely used read-outs for studying ERK pathway activation, phosphorylation state, and downstream transcriptional responses in cell lysates and tissue sections. Reactivity has been confirmed against Human, Mouse, and Rat samples, making it suitable for comparative work across the most common experimental models. The polyclonal format offers epitope redundancy, which is advantageous when working with post-translationally modified ERK1 or when probing samples where antigen accessibility may be limited. For routine handling, the product is shipped cold and should be aliquoted upon arrival to minimize freeze/thaw cycles; long-term storage at -20 °C in the supplied glycerol-containing buffer preserves activity. Intended for research use only, the reagent is well suited to signal transduction studies, oncology and neurodegeneration research, and characterization of drug responses that converge on the MAPK pathway. Each lot is released by Antibodies.com to support reproducible ERK1 detection in basic and translational laboratory workflows.