Anti-ERK 1 / 2 Antibody

The ERK1/2 (Extracellular signal-Regulated Kinase 1 and 2) signaling axis is a central branch of the MAPK cascade, relaying mitogenic, stress, and differentiation cues through kinase phosphorylation events. Antibodies.com offers this affinity-purified polyclonal reagent for laboratories interrogating pathway dynamics across mammalian systems.

Each 100 µl vial of unconjugated primary antibody is raised in rabbit and validated for western blot, immunohistochemistry, and ELISA workflows. Cross-reactivity with human, mouse, and rat samples supports parallel studies in transformed cell lines, primary tissue sections, and whole-cell lysates. The polyclonal format tolerates multiple post-translational modification states of the kinase, enabling downstream readouts of activation under varied stimulation conditions.

Typical research contexts include oncology screens probing proliferative signaling, neuroscience work mapping activity-dependent phosphorylation, and pharmacology programs assessing small-molecule inhibitors of the MAPK cascade. Single-use aliquots drawn from the stock vial limit freeze-thaw cycling and help preserve lot-to-lot consistency across long studies. For research use only.