Anti-ERG Antibody

Antibodies.com offers this recombinant rabbit monoclonal reagent raised against the ERG (ETS-Related Gene) transcription factor. The unconjugated antibody is supplied as 100 µl in a TBS pH7.4 buffer containing 1% BSA, 40% glycerol, and 0.05% sodium azide as preservative.

Validated applications include Western blot, immunocytochemistry/immunofluorescence, and immunohistochemistry, with reactivity confirmed against human, mouse, and rat samples. ERG functions as a nuclear transcription factor and serves as a robust marker for vascular endothelial cells, making this reagent useful for studies of angiogenesis and vascular development.

In pathology workflows, ERG immunostaining is used to identify prostatic adenocarcinoma cases harboring the TMPRSS2-ERG gene fusion, one of the most frequent genomic rearrangements in prostate cancer. Researchers can apply the antibody to formalin-fixed paraffin-embedded tissue sections, cultured cell preparations, and protein lysates to investigate oncogenic signaling, endothelial differentiation, and vascular biology. Recombinant production ensures consistent clonality and reproducible staining across independent experimental runs.