Anti-ERCC6 Antibody

ERCC6 encodes the Cockayne syndrome B (CSB) protein, an ATP-dependent SWI/SNF-family chromatin remodeler that recruits repair machinery to lesion-stalled RNA polymerase II on actively transcribed strands. The Antibodies.com anti-ERCC6 polyclonal reagent is raised in rabbit and validated for Western blot detection of endogenous protein from human, mouse, and rat samples.

Provided as 50 µl at 1 mg/ml in phosphate-buffered saline (pH ~7.3) with 0.05% sodium azide as preservative, this unconjugated primary antibody fits cleanly into standard chemiluminescent workflows and pairs with HRP- or fluorophore-conjugated secondaries. Cross-reactivity with mouse and rat orthologs makes it useful for comparative work in cell lines, primary cultures, and tissue lysates.

Typical research applications include probing UV-induced DNA damage response, transcription-coupled nucleotide excision repair activity, and expression analysis in Cockayne syndrome, UV-sensitive syndrome, and Cockayne syndrome-like disease models.

For research use only.