Anti-ERCC1 Antibody

ERCC1 (Excision Repair Cross-Complementation Group 1) partners with XPF to form the ERCC1-XPF heterodimeric endonuclease that performs 5' incisions during nucleotide excision repair of bulky DNA adducts and ultraviolet-induced photolesions. This unconjugated rabbit polyclonal antibody from Antibodies.com is validated for western blot analysis and immunohistochemistry on human and mouse specimens, supporting research into DNA damage response pathways, interstrand crosslink repair, and platinum resistance mechanisms in non-small cell lung cancer and other solid tumour models. The reagent is supplied as 100 µl of polyclonal antiserum in an unconjugated format, allowing laboratories to pair it with their own secondary detection chemistry for chromogenic or fluorescence imaging workflows. Reactivity has been confirmed against human and mouse ERCC1, and the rabbit host background is compatible with standard anti-rabbit IgG secondaries used in routine immunoblotting and tissue section staining protocols.