Anti-ERCC1 Antibody

ERCC1 is a critical component of the nucleotide excision repair pathway, forming a heterodimer with XPF (ERCC4) to perform 5' endonucleolytic cleavage during DNA damage repair. This rabbit polyclonal antibody from Antibodies.com targets ERCC1 for use in Western blot, immunohistochemistry, and immunofluorescence workflows across human, mouse, and rat samples.

Supplied as an unconjugated polyclonal reagent at 1 mg/ml in PBS with 0.1% sodium azide and 50% glycerol, the 100 µl vial format offers flexibility for both standard and exploratory protocols. The antibody enables detection of ERCC1 expression in tumor specimens and cell lines, supporting research into chemotherapy response biomarkers, particularly platinum-based agent sensitivity in non-small cell lung cancer and ovarian carcinoma studies.

This reagent underpins investigations of DNA repair mechanisms, interstrand crosslink processing, and genomic stability, pairing well with immunostaining and lysate-based detection methods. Storage at -20 degrees C in aliquots preserves activity across multiple freeze-thaw cycles for long-term laboratory programs.