Anti-ERBB4 Antibody

ERBB4 (HER4) is a 180 kDa receptor tyrosine kinase of the ErbB family that becomes activated by neuregulin ligands and signals through PI3K/AKT and MAPK cascades; this Antibodies.com rabbit polyclonal IgG reagent detects the human and mouse protein in western blot experiments, pairing with cell lysate workflows that probe downstream pathway activity and isoform-specific banding patterns such as the JM-a/CYT-1 versus JM-b/CYT-2 splice variants. The antibody is supplied as 100 µl of unconjugated antiserum, ready for conjugation to HRP, biotin, or fluorescent labels of choice, and the polyclonal format offers multi-epitope recognition against intracellular and extracellular regions of HER4. This Primary Antibodies reagent is suited to laboratories comparing ERBB4 expression across breast cancer, glioma, and colorectal carcinoma models, where the receptor is studied as both a marker of endocrine therapy responsiveness in ER-positive disease and a contributor to tumor cell proliferation. Researchers can pair it with monoclonal tools when confirming knockout cell lines, patient-derived xenograft lysates, or developmental tissues in which ERBB4 supports cardiac neural crest migration and neuronal differentiation. Aliquot upon arrival and store at the temperature indicated on the data sheet to preserve titer across multiple blotting cycles, and cross-reactivity with both human and mouse samples supports parallel studies of normal and disease-state receptor biology without switching hosts.