Anti-ERBB3 Antibody

ERBB3 (also called HER3) is a 180 kDa receptor tyrosine kinase of the ErbB family that lacks intrinsic catalytic activity and instead signals through heterodimerization with EGFR, HER2, or HER4. This Rabbit polyclonal IgG antibody, supplied by Antibodies.com at 100 µL, targets an epitope of human ERBB3 and cross-reacts with mouse and rat orthologs, making it useful for translational studies across species.

Validated applications include Western blot (WB) detection of the full-length receptor and cleaved intracellular fragments, and immunohistochemistry (IHC) on formalin-fixed paraffin-embedded tissues, where it is commonly used to assess HER3 expression in breast, gastric, colorectal, and head and neck tumor specimens. The unconjugated format allows flexible pairing with enzyme- or fluorophore-labeled secondary reagents depending on the chosen detection chemistry.

ERBB3 is clinically relevant as a compensatory signaling node in HER2-positive breast cancers undergoing HER2-targeted therapy, and the antibody supports research into resistance mechanisms, PI3K/AKT pathway activation, and dimerization-dependent signaling. Store the antibody at 4 °C for short-term use and aliquot at -20 °C for long-term storage to preserve activity over multiple freeze-thaw cycles.