Anti-ERBB2 (phospho Y1248) Antibody

A rabbit polyclonal IgG antibody from Antibodies.com that selectively recognizes human ERBB2 (also called HER2) when phosphorylated on tyrosine 1248, a key autophosphorylation site within the receptor tyrosine kinase activation loop. This unconjugated primary antibody is supplied as a 50 µl liquid aliquot and is validated for Western blot detection of HER2 signaling in cell lysates and tumor-derived samples.

Because the Y1248 phospho-epitope reports active receptor signaling, this reagent is commonly used in breast cancer research, studies of HER2-positive disease, and investigations of receptor tyrosine kinase pathway activation downstream of ErbB receptor dimerization. The polyclonal format offers recognition of multiple epitopes surrounding the phospho-Y1248 site, supporting consistent band detection in Western blot workflows when paired with appropriate HRP- or fluorophore-conjugated secondary antibodies and phosphatase-treated negative controls.

Host species is rabbit, clonality is polyclonal, isotype is IgG, the antibody is unconjugated, and reactivity is confirmed for human ERBB2. Storage at 4 °C is recommended; protect from light, aliquot on first use to limit freeze-thaw cycles, and avoid prolonged storage at room temperature. For research use only; not intended for diagnostic or therapeutic applications.