Anti-ErbB-4 / HER4 Antibody

ErbB-4 (HER4) is a receptor tyrosine kinase in the EGFR family, and phosphorylation at tyrosine 1284 marks its activated state within downstream signaling cascades. This rabbit polyclonal antibody from Antibodies.com selectively detects the phospho-Y1284 form of ErbB-4, enabling researchers to monitor receptor activation rather than baseline expression levels. Validated for Western Blot applications on Human, Mouse, and Rat samples, the reagent is supplied as a 100 µl vial at 1 mg/ml in PBS containing 0.1% sodium azide and 50% glycerol as a cryoprotective stabilizer. The unconjugated polyclonal format provides broad epitope coverage around the Y1284 phospho-site, supporting studies of heregulin (NRG1)-driven signaling, breast cancer cell line profiling, and cardiac or neural development models in which ErbB-4 activation has been implicated. Researchers working on NRG1/ErbB pathway biology, trastuzumab-resistant tumor lines, or developmental ErbB-4 phosphorylation can pair this reagent with total ErbB-4 antibodies to compare phosphorylated and total receptor levels by immunoblotting.