Anti-ErbB-3 Antibody

Generated in rabbit against ErbB-3, this polyclonal antibody from Antibodies.com detects the HER3 receptor tyrosine kinase across human, mouse, and rat samples in western blot and immunohistochemistry workflows. The unconjugated reagent is supplied at 1 mg/ml in PBS with 0.1% sodium azide and 50% glycerol as a cryoprotectant, and the 100 µl vial is sized for repeated experimental use.

ErbB-3 (also called HER3) belongs to the EGFR/ErbB receptor family, where it heterodimerizes with ErbB-2/HER2 and other family members to drive PI3K-Akt signaling implicated in several solid tumors, including breast, gastric, and colorectal carcinomas. Research applications of this reagent therefore cover receptor signaling pathway analysis, biomarker validation in patient-derived tissue sections by IHC, and pre-clinical evaluation of HER3-targeted therapeutics, including investigation of resistance mechanisms to anti-EGFR and anti-HER2 agents in cell-based assays.

Sodium azide in the formulation precludes live-cell labeling but is compatible with fixed-cell immunohistochemistry and standard western blotting of cell or tissue lysates, supporting both routine antibody validation and deeper mechanistic studies of ErbB-driven oncogenic programs.