Anti-ERAP1 Antibody

Endoplasmic Reticulum Aminopeptidase 1 (ERAP1) is a zinc-dependent aminopeptidase of the endoplasmic reticulum that trims N-terminal residues from precursor peptides, shaping the repertoire loaded onto MHC class I molecules. The Anti-ERAP1 Antibody offered by Antibodies.com is a rabbit polyclonal primary antibody supplied unconjugated in a 100 µl volume as an IgG, validated for western blot detection in human and mouse samples.

ERAP1 plays well-characterised roles in antigen processing and immune surveillance, and genome-wide association studies have linked its common variants — notably K528R and Q730E — to ankylosing spondylitis, Behçet's disease, and other inflammatory conditions, sustaining active interest in its regulation. Researchers use this reagent to probe ERAP1 abundance in cell lysates, examine how cytokine stimulation alters trimming activity, and explore how polymorphic ERAP1 forms shift the peptides presented by MHC class I.

For western blot, banding patterns are consistent with the ~110 kDa mature ERAP1 protein. Aliquoting upon receipt is recommended to limit freeze-thaw cycles and to preserve reagent performance across multiple experiments, with HRP-conjugated secondary antibodies supporting chemiluminescent visualisation.