Anti-EPPIN Antibody

This rabbit polyclonal antibody recognizes EPPIN (Epididymal Protease Inhibitor), a secreted sperm-surface protein characterized by tandem WAP (four-disulfide-core) domains and a C-terminal Kunitz-type protease inhibitor motif. The reagent from Antibodies.com is supplied as 100 µl of unconjugated antiserum and is validated for western blot (WB) and immunohistochemistry (IHC) on human and mouse specimens, supporting investigations of spermatogenesis, sperm maturation, capacitation, and male reproductive tract biology.

EPPIN engages semenogelin-I on the post-ejaculate sperm surface and contributes to the regulated protease cascade that remodels the sperm membrane, with altered expression implicated in idiopathic male infertility and explored as a candidate target in non-hormonal contraceptive development. The polyclonal format enables detection of multiple epitopes along the ~16 kDa mature chain, including any truncated forms that may arise during epididymal transit, and is suitable for probing both fixed tissue sections and reduced lysates prepared from testis, caput, and cauda epididymidis. Aliquot the antiserum on arrival to limit repeated freeze-thaw cycles of the working stock.