Anti-EphB2 Antibody

Raised in rabbits against EphB2, this unconjugated polyclonal reagent from Antibodies.com recognizes the human ephrin type-B receptor 2, a 120 kDa transmembrane receptor tyrosine kinase that binds membrane-anchored ephrin-B ligands to direct contact-dependent cell-cell communication. The antibody is supplied as 100 µl of ready-to-use reagent validated for Western blot, immunohistochemistry, and ELISA workflows, and is reactive with human samples. EphB2 plays central roles in cell sorting, axon guidance, synaptic plasticity, intestinal crypt patterning, and vascular remodeling, and is widely studied in colorectal and prostate cancer progression, glioblastoma invasion, and bone homeostasis. Researchers commonly deploy this reagent to map receptor localization in intestinal epithelium, neuronal tissue, and tumor biopsies, to interrogate Eph/ephrin forward and reverse signaling cascades, and to validate transcriptomic findings on EPHB2 dysregulation. The polyclonal format delivers multi-epitope recognition of the target, while the unconjugated formulation gives flexibility for downstream labeling with fluorophores, biotin, or HRP depending on the chosen assay. Refrigerated storage preserves reagent activity for routine laboratory use.