Anti-EPB41 Antibody

EPB41 encodes erythrocyte membrane protein band 4.1, a scaffolding component of the red cell membrane skeleton that anchors the short actin filaments of the junctional complex to glycophorin and the underlying spectrin lattice. This rabbit polyclonal antibody from Antibodies.com is supplied as 100 µl of unconjugated IgG at 1 mg/ml in PBS containing 0.1% sodium azide and 50% glycerol.

The reagent has been validated for western blot, immunohistochemistry, and immunofluorescence on human, mouse, and rat samples, supporting cross-species studies of cytoskeletal organization in erythroid cells, where EPB41 was originally characterized, as well as in neurons and epithelial tissues where 4.1 family members contribute to membrane domain organization. The unconjugated format is compatible with HRP- or fluorophore-conjugated secondary reagents chosen by the experimenter.

Store the vial at -20°C and dilute into single-use aliquots to limit freeze-thaw cycles; the glycerol component acts as a cryoprotectant that maintains antibody stability under repeated access, while sodium azide serves as a microbial preservative. This primary reagent is intended for research use only and supports investigations into red blood cell morphology, hereditary elliptocytosis, and EPB41-containing protein complexes at the plasma membrane.