Anti-ENPP7 Antibody

This rabbit polyclonal reagent from Antibodies.com targets ENPP7 (Ectonucleotide Pyrophosphatase/Phosphodiesterase 7), an intestinal alkaline sphingomyelinase that hydrolyzes sphingomyelin to generate ceramide and phosphocholine in the gut mucosa. ENPP7 is a member of the ectonucleotide pyrophosphatase/phosphodiesterase family, with primary expression in intestinal enterocytes and the liver, where it contributes to dietary sphingomyelin digestion, intestinal cholesterol uptake, and mucosal inflammation. Altered ENPP7 expression has been documented in colon carcinoma tissue, making the protein a marker of interest in gastrointestinal cancer research. The product is supplied as 100 µL of unconjugated antiserum in a vial, validated for Western blot and immunohistochemistry on human samples. Raised in rabbit as a polyclonal, the antibody recognizes multiple epitopes across the human ENPP7 protein, allowing detection in formalin-fixed paraffin-embedded tissue sections and on immunoblots of cell lysates. The unconjugated format lets researchers pair the reagent with secondary antibodies, fluorophores, or chromogens of their choice. Refrigerate on arrival and protect from light to maintain activity across the shelf life of the product.