Anti-Endoglin Antibody

Endoglin (CD105) is a 180 kDa transmembrane glycoprotein expressed predominantly on vascular endothelial cells, where it acts as an accessory subunit of the TGF-β receptor complex and modulates angiogenic signaling. The Anti-Endoglin Antibody from Antibodies.com is a rabbit polyclonal reagent supplied at 1 mg/ml in PBS containing 0.1% Sodium Azide and 50% glycerol, validated for Western blot detection of Endoglin in both human and mouse samples.

This unconjugated primary antibody supports research into tumor angiogenesis, hereditary hemorrhagic telangiectasia (HHT1, also known as Osler-Weber-Rendu syndrome), preeclampsia, and vascular development. Each vial provides 100 µl of ready-to-dilute reagent. For long-term storage, keep the antibody frozen at -20 °C in small aliquots to limit freeze-thaw cycles, and protect from light during handling.

Working dilutions for Western blot should be optimized empirically based on Endoglin abundance in the lysate. The polyclonal format ensures recognition of multiple epitopes, which improves tolerance for minor sample-to-sample variation in protein processing and post-translational modification state.