Anti-ENDOG Antibody

Manufactured by Antibodies.com, this primary antibody is a rabbit polyclonal reagent raised against Endonuclease G (ENDOG), the 33 kDa mitochondrial nuclease implicated in caspase-independent apoptotic DNA fragmentation. The antibody is supplied as a 50 µl liquid aliquot at a concentration of 1 mg/ml, formulated in PBS containing 50% glycerol and sodium azide as a preservative, and is unconjugated, allowing users to pair it with their preferred secondary detection reagents. It is of the IgG isotype, has been affinity purified, and is validated for Western Blot (WB) applications at a recommended working dilution of 1:500 – 1:2,000. Species reactivity covers Human, Mouse, and Rat samples, making it suitable for comparative work across these common research models. For stability, the vial is shipped at 4 °C and, upon receipt, should be aliquoted and stored at –20 °C, with repeated freeze/thaw cycles avoided. The immunogen corresponds to a recombinant fusion protein spanning amino acids 49–297 of human Endo G (NP_004426.2), and the antibody is intended for research use only and not for diagnostic or therapeutic applications. Supplied through AFMS, this Anti-ENDOG polyclonal is a versatile tool for laboratories studying mitochondrial pathways, programmed cell death, and chromatin degradation during apoptosis.