Anti-ELK1 (phospho S383) Antibody

This rabbit polyclonal antibody from Antibodies.com recognizes ELK1 only when phosphorylated at serine 383, a key activating modification catalyzed by ERK1/2 within the MAPK signaling pathway. ELK1 is a member of the Ets family of transcription factors, and phosphorylation at S383 drives dimerization with SRF and induction of immediate-early genes such as c-Fos. The reagent is supplied as a 100 µl unconjugated IgG fraction and is validated for Western blot and immunohistochemistry on human, mouse, and rat specimens. Researchers studying growth factor signaling, neuronal activity-dependent transcription, or oncogenic Ras/Raf/MEK/ERK output use this antibody to distinguish the active, phosphorylated pool from total ELK1 protein. For research use only, supplied as a liquid vial suitable for storage at -20°C with brief cold handling, the antibody should be aliquoted to limit freeze-thaw cycles and protect from light to preserve phospho-epitope recognition across repeated experiments.