Anti-EIF5A Antibody

Eukaryotic translation initiation factor 5A (EIF5A) is a small ~18 kDa protein notable for its hypusine post-translational modification at lysine 50, which is essential for its role in peptide bond formation at proline-rich sequences during translation elongation. Distributed by Antibodies.com as a primary antibody reagent, this unconjugated rabbit polyclonal reagent recognizes both EIF5A1 and the related EIF5A2 isoform, and the 50 µl aliquot is validated for western blot (WB), immunohistochemistry (IHC), and immunofluorescence (IF) workflows across human, mouse, and rat sample preparations.

EIF5A participates in mRNA translation, nucleocytoplasmic transport, and stress-response signaling, and has been implicated in proliferation, apoptosis, viral replication, and tumor biology, supporting studies in cell biology, cancer research, and host-pathogen interaction. The polyclonal format enables multi-epitope recognition, useful in tissues where EIF5A isoform expression varies. Storage at -20 °C in working aliquots preserves activity through repeated freeze-thaw cycles, and the reagent is intended for research use only.