Anti-EIF4G1 (phospho S1232) Antibody

This rabbit polyclonal antibody from Antibodies.com specifically targets EIF4G1 phosphorylated at serine 1232, a modification linked to regulation of cap-dependent translation initiation and cellular stress responses. EIF4G1 acts as a scaffold within the eIF4F complex, recruiting ribosomes to mRNA 5' caps, and phosphorylation at S1232 modulates its activity in signalling cascades downstream of MNK and related kinases.

Validated for Western blot and immunohistochemistry on human samples, the reagent is supplied as an unconjugated IgG in a 50 µl vial volume. Researchers studying translational control, stress granule biology, or signalling pathways can use the antibody to detect endogenous levels of phosphorylated EIF4G1 in cell lysates and tissue sections. The polyclonal format provides recognition of multiple epitopes surrounding the phospho-S1232 site, supporting clear detection when paired with appropriate blocking buffers and secondary reagents in standard immunodetection workflows.