Anti-EIF4E2 Antibody

This rabbit polyclonal antibody from Antibodies.com specifically targets EIF4E2 (also known as 4EHP or eIF4E homologous protein), a cap-binding protein that functions as a translational repressor rather than a canonical translation initiation factor. The unconjugated IgG reagent is supplied as 100 µl of polyclonal antisera and is validated for Western blot detection of the endogenous protein in human, mouse, and rat samples.

EIF4E2 competes with eIF4E for m7G cap binding and is recruited to mRNA targets by interacting partners such as the 4E-T family and the CCR4-NOT deadenylase complex, contributing to translation silencing and mRNA decay. It is frequently studied in the context of microRNA-mediated gene regulation, adult neurogenesis, and stress-responsive translation control, and altered 4EHP expression has been reported in several cancer models. The reagent supports reproducible chemiluminescent Western blot workflows and is compatible with standard HRP-conjugated secondary antibodies.

Key features:
- Host: Rabbit polyclonal IgG
- Target: EIF4E2 (4EHP)
- Reactivity: Human, Mouse, Rat
- Application: Western blot
- Format: 100 µl unconjugated polyclonal reagent