Anti-EIF4B Antibody - Identical to Abcam (ab186856)

EIF4B (Eukaryotic Translation Initiation Factor 4B) is a key regulator of cap-dependent protein synthesis, where it cooperates with eIF4A and eIF4F to promote ribosome recruitment and scanning on mRNA templates. Phosphorylation of EIF4B by mTORC1, S6K1, and PKC integrates translation initiation with growth factor, nutrient, and stress signaling, making the protein a widely studied node in oncogenic and metabolic research pathways.

This unconjugated rabbit polyclonal IgG reagent from Antibodies.com recognizes endogenous EIF4B and has been validated for Western blot, Immunohistochemistry, Immunofluorescence, and Immunoprecipitation across human and mouse samples. The polyclonal format yields recognition of multiple epitopes on the target, useful for capturing native complexes in IP and for detecting the protein in fixed tissue sections.

Researchers deploy this antibody to characterize translation initiation in B-cell lymphoma and other cancers where EIF4B is amplified or overexpressed, to probe mTOR pathway activity downstream of rapamycin treatment, and to follow EIF4B phosphorylation dynamics during neuronal development, axon regeneration, and cellular stress responses. Supplied as 100 µl of liquid antiserum, the reagent integrates directly into standard immunolabeling pipelines without further conjugation.