Anti-EIF2S2 Antibody

An unconjugated rabbit IgG primary antibody from Antibodies.com raised against the beta subunit (eIF2β) of eukaryotic translation initiation factor 2, a heterotrimeric GTP-binding complex that delivers initiator methionyl-tRNA to the 40S ribosomal subunit during cap-dependent translation. The reagent is supplied as 100 µl of liquid polyclonal IgG at 1.0 mg/mL in a single vial, with reactivity verified in human, mouse, and rat samples. Validated applications are western blot (WB) and immunohistochemistry (IHC) on formalin-fixed paraffin-embedded sections, supporting studies that probe translational control, ternary complex assembly, and the integrated stress response where eIF2α phosphorylation intersects eIF2β function. The polyclonal format broadens epitope coverage across the 38 kDa EIF2S2 polypeptide (UniProt P20042; Gene ID 8894) and tolerates minor sequence variation between isoforms and across species. For routine use, store refrigerated at 4°C; for longer-term storage, aliquot and freeze at -20°C, avoiding repeated freeze-thaw cycles to preserve antibody activity. The unconjugated presentation lets researchers pair it with their preferred secondary reporter — HRP, alkaline phosphatase, or a fluorophore — for chemiluminescent, chromogenic, or fluorescence detection in cell lysates and tissue sections.